Evolutionary History of a Specialized P450 Propane Monooxygenase
نویسندگان
چکیده
منابع مشابه
Evolutionary history of a specialized p450 propane monooxygenase.
The evolutionary pressures that shaped the specificity and catalytic efficiency of enzymes can only be speculated. While directed evolution experiments show that new functions can be acquired under positive selection with few mutations, the role of negative selection in eliminating undesired activities and achieving high specificity remains unclear. Here we examine intermediates along the 'line...
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All known P450-containing monooxygenase systems share common structural and functional domain architecture. Apart from P450 itself, these systems can comprise several fundamentally different protein components or domains, all of which are shared by other multicomponent/multidomain enzyme systems with various functions: FAD flavoprotein or domain, FMN domain, Fe2S2 ferredoxin, Fe3S4 ferredoxin, ...
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Insecticide resistance is one of the major obstacles to the control of agriculturally important arthropod pests. Resistance results in increased application frequencies, increased dosages, decreased yields, environmental damage, and outbreaks of human and animal diseases when vectors cannot be controlled. The World Health Organization has called insecticide resistance "the biggest single obstac...
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The results of a limited number of studies on echinoderms provide evidence for the presence of a cytochrome P450 monooxygenase system in representatives of three classes of the phylum Echinodermata: the asteroids (sea stars), holothuroids (sea cucumbers) and echinoids (sea urchins). The monooxygenase system has been demonstrated to be involved in the metabolism of xenobiotic compounds, but is a...
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ژورنال
عنوان ژورنال: Journal of Molecular Biology
سال: 2008
ISSN: 0022-2836
DOI: 10.1016/j.jmb.2008.06.060